Enroll-HD

Publicaciones

Publicaciones que aprovechan datos, muestras biológicas y/o infraestructura del Enroll-HD.

Publicaciones

Enroll-HD es a la vez un estudio observacional mundial y una plataforma de investigación clínica que respalda varios estudios y ensayos, con el objetivo general de acelerar el desarrollo terapéutico de la EH. Los datos clínicos y las muestras biológicas recopilados en Enroll-HD y otros estudios de HD están disponibles a través de la plataforma Enroll-HD para cualquier investigador verificado según la Política de acceso a datos clínicos y muestras biológicas para extraer el mayor conocimiento posible. Como siempre, estamos enormemente agradecidos a los miles de participantes y familias de todo el mundo que dan desinteresadamente su tiempo y energía, así como al dedicado personal de los centros clínicos que hacen posible el Enroll-HD.

Al publicar sus hallazgos, se espera que los investigadores que utilicen estos datos y muestras biológicas respeten las Política de publicación Enroll-HD, incluido el reconocimiento total de las personas que contribuyeron a la recopilación de datos del Enroll-HD. Todas las publicaciones alojadas aquí han utilizado los conjuntos de datos de Enroll-HD que se ponen a disposición periódicamente e ilustran algunas de las áreas de investigación de la EH en las que Enroll-HD está influyendo directamente.

Si su publicación que utiliza datos Enroll-HD no está incluida en esta galería, o si conoce una publicación que debería incluirse, háganoslo saber en info@chdifoundation.org.

Authors

Title

Journal

Achenbach J, Saft C

Data from Enroll-HD: Is the prevalence of juvenile and pediatric Huntington's disease overestimated?
Parkinsonism Relat Disord
Jul 01, 2021
88 :1-2
PMID: 34049236

Lang C, Gries C, Lindenberg KS, Lewerenz J, Uhl S, Olsson C, Samzelius J, Landwehrmeyer GB

Monitoring the motor phenotype in Huntington's disease by analysis of keyboard typing during real life computer use
J Huntingtons Dis
Jun 09, 2021
10 (2) :259-268
PMID: 33459656

van der Zwaan KF, Jacobs M, van Zwet EW, Roos RAC, de Bot ST

Predictors of working capacity changes related to Huntington's disease: A longitudinal study
J Huntingtons Dis
Jun 09, 2021
10 (2) :269-276
PMID: 33523014

Achenbach J, Faissner S, Saft C

Differential diagnosis of Chorea-HIV infection delays diagnosis of Huntington's disease by years
Brain Sci
May 27, 2021
11 (6) :710
PMID: 34071882

Ghazaleh N, Houghton R, Palermo G, Schobel SA, Wijeratne PA, Long JD

Ranking the predictive power of clinical and biological features associated with disease progression in Huntington's disease
Front Neurol
May 21, 2021
12 :678484
PMID: 34093422
PMCID: 8176643

Symonds AL, Macerollo A, Foy K, Alusi SH, Davies R

Genetic and environmental contributors to neurodegeneration: An exploration of the effects of alcohol on clinical features of Huntington's disease using the Enroll-HD global platform
Int J Environ Res Public Health
May 12, 2021
18 (10) :5113
PMID: 34065918

Schultz JL, Saft C, Nopoulos PC

Association of CAG repeat length in the Huntington gene with cognitive performance in young adults
Neurology
May 11, 2021
96 (19) :e2407-e2413
PMID: 33692166

Hentosh S, Zhu L, Patino J, Furr JW, Rocha NP, Furr Stimming E

Sex differences in Huntington's disease: evaluating the Enroll-HD database
Mov Disord Clin Pract
Abr 01, 2021
8 (3) :420-426
PMID: 33816672

Ogilvie AC, Gonzalez-Alegre P, Schultz JL

Diabetes mellitus is associated with an earlier age of onset of Huntington's disease
Mov Disord
Abr 01, 2021
36 (4) :1033-1034
PMID: 33368647

Oosterloo M, de Greef BTA, Bijlsma EK, Durr A, Tabrizi SJ, Estevez-Fraga C, de Die-Smulders CEM, Roos RAC

Disease onset in Huntington's disease: when is the conversion?
Mov Disord Clin Pract
Mar 31, 2021
8 (3) :352-360
PMID: 33816663
PMCID: 8015887

Cain KK, Flanigan JL, Dalrymple WA, Patrie J, Harrison MB, Barrett MJ

The effect of education on symptom onset and severity of Huntington's disease
Mov Disord Clin Pract
Mar 30, 2021
8 (4) :555-562
PMID: 33981788
PMCID: 8088098

Achenbach J, Saft C, Faissner S

Longitudinal evaluation of the effect of tricyclic antidepressants and neuroleptics on the course of Huntington's disease-data from a real world cohort
Brain Sci
Mar 25, 2021
11 (4) :413
PMID: 33805940

McLaren B, Andrews SC, Glikmann-Johnston Y, Mercieca EC, Murray NWG, Loy C, Bellgrove MA, Stout JC

Feasibility and initial validation of 'HD-Mobile', a smartphone application for remote self-administration of performance-based cognitive measures in Huntington's disease
J Neurol
Feb 01, 2021
268 (2) :590-601
PMID: 32880724

Mühlbäck A, Frank W, Klempířová O, Bezdíček O, Schmitt L, Hofstetter N, Landwehrmeyer GB, Klempíř J

Validation study of a German cognitive battery for Huntington's disease: Relationship between cognitive performance, functional decline, and disease burden
Arch Clin Neuropsychol
Ene 15, 2021
36 (1) :74-86
PMID: 32613239

Griffin BA, Booth MS, Busse M, Wild EJ, Setodji C, Warner JH, Sampaio C, Mohan A

Estimating the causal effects of modifiable, non-genetic factors on Huntington disease progression using propensity score weighting
Parkinsonism Relat Disord
Ene 13, 2021
83 :56-62
PMID: 33476879

Ranganathan M, Kostyk SK, Allain DC, Race JA, Daley AM

Age of onset and behavioral manifestations in Huntington's disease: An Enroll-HD cohort analysis
Clin Genet
Ene 01, 2021
99 (1) :133-142
PMID: 33020896

Carlozzi NE, Boileau NR, Roberts A, Dayalu P, Hanifan DL, Miner JA, Claassen D, Provost EM

Understanding speech and swallowing difficulties in individuals with Huntington disease: Validation of the HDQLIFE Speech Difficulties and Swallowing Difficulties Item Banks
Qual Life Res
Ene 01, 2021
30 (1) :251-265
PMID: 32839864
PMCID: 7854808

Langbehn DR, Hersch S

Clinical outcomes and selection criteria for prodromal Huntington's disease trials
Mov Disord
Dic 01, 2020
35 (12) :2193-2200
PMID: 32686867
PMCID: 7818458

Lu AT, Narayan P, Grant MJ, Langfelder P, Wang N, Kwak S, Wilkinson H, Chen RZ, Chen J, Simon Bawden C, Rudiger SR, Ciosi M, Chatzi A, Maxwell A, Hore TA, Aaronson J, Rosinski J, Preiss A, Vogt TF, Coppola G, Monckton D, Snell RG, William Yang X, Horvath S

DNA methylation study of Huntington's disease and motor progression in patients and in animal models
Nat Commun
Sep 10, 2020
11 (1) :4529
PMID: 32913184

Schultz JL, Harshman LA, Langbehn DR, Nopoulos PC

Hypertension is associated with an earlier age of onset of Huntington's disease
Mov Disord
Sep 01, 2020
35 (9) :1558-1564
PMID: 32339315

Mills JA, Long JD, Mohan A, Ware JJ, Sampaio C

Cognitive and motor norms for Huntington's disease
Arch Clin Neuropsychol
Sep 01, 2020
35 (6) :671–682
PMID: 32407458

Schultz JL, Moser AD, Nopoulos PC

The association between CAG repeat length and age of onset of juvenile-onset Huntington's disease
Brain Sci
Ago 20, 2020
10 (9) :E575
PMID: 32825467

Achenbach J, von Hein SM, Saft C

Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic-rigid motor subtypes in Huntington's disease
Brain Behav
Ago 01, 2020
10 (8) :e01704
PMID: 32530575
PMCID: 7428484

Kwa L, Larson D, Yeh C, Bega D

Influence of age of onset on Huntington's disease phenotype
Tremor Other Hyperkinet Mov
Jul 09, 2020
10 (21)
PMID: 32775035
PMCID: 7394225

Jaini A, Yomtoob J, Yeh C, Bega D

Understanding HD psychosis: an analysis from the Enroll-HD database
Tremor Other Hyperkinet Mov
Jul 07, 2020
10 (16)
PMID: 32775030
PMCID: 7394199

Steventon JJ, Rosser AE, Hart E, Murphy K

Hypertension, antihypertensive use and the delayed-onset of Huntington's disease
Mov Disord
Jun 30, 2020
35 (6) :937-946
PMID: 32017180
PMCID: 7317197

Yhnell E, Furby H, Lowe RS, Brookes-Howell LC, Drew CJG, Playle R, Watson G, Metzler-Baddeley C, Rosser AE, Busse ME

A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD)
Pilot Feasibility Stud
Jun 19, 2020
6 :88
PMID: 32577299
PMCID: 7304172

Witkowski G, Jachinska K, Stepniak I, Ziora-Jakutowicz K, Sienkiewicz-Jarosz H

Alterations in transcranial sonography among Huntington's disease patients with psychiatric symptoms
J Neural Transm (Vienna)
Jun 16, 2020
127 (7) :1047-1055
PMID: 32285254
PMCID: 7293686

Gaßner H, Jensen D, Marxreiter F, Kletsch A, Bohlen S, Schubert R, Muratori LM, Eskofier B, Klucken J, Winkler J, Reilmann R, Kohl Z

Gait variability as digital biomarker of disease severity in Huntington's disease
J Neurol
Jun 05, 2020
267 (6) :1594-1601
PMID: 32048014
PMCID: 7293689

De Lucia N, Peluso S, Roca A, De Michele G, Trojano L, Salvatore E

Perseverative behavior on verbal fluency task in patients with Huntington's disease: a retrospective study on a large patient sample
Arch Clin Neuropsychol
Jun 02, 2020
35 (4) :358-364
PMID: 31813981

Gunn S, Maltby J, Dale M

Assessing mental health difficulties of persons with Huntington's disease: Does informant presence make a difference?
J Neuropsychiatry Clin Neurosci
Jun 01, 2020
32 (3) :244-251
PMID: 32102601

Harris KL, Kuan WL, Mason SL, Barker RA

Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington's disease (Enroll-HD)
J Neurol Neurosurg Psychiatry
Jun 01, 2020
91 (6) :622-630
PMID: 32229581
PMCID: 7279191

Julayanont P, Heilman KM, McFarland NR

Early-motor phenotype relates to neuropsychiatric and cognitive disorders in Huntington's disease
Mov Disord
May 02, 2020
35 (5) :781-788
PMID: 31922295

Ellis N, Tee A, McAllister B, Massey T, McLauchlan D, Stone T, Correia K, Loupe J, Kim KH, Barker D, Hong EP, Chao MJ, Long JD, Lucente D, Vonsattel JPG, Pinto RM, Elneel KA, Ramos EM, Mysore JS, Gillis T, Wheeler VC, Medway C, Hall L, Kwak S, Sampaio C, Ciosi M, Maxwell A, Chatzi A, Monckton DG, Orth M, Landwehrmeyer GB, Paulsen JS, Shoulson I, Myers RH, van Duijn E, Rickards H,…Holmans P

Genetic risk underlying psychiatric and cognitive symptoms in Huntington's disease
Biol Psychiatry
May 01, 2020
87 (9) :857-865
PMID: 32087949
PMCID: 7156911

Steventon JJ, Furby H, Ralph J, O’Callaghan P, Rosser AE, Wise RG, Busse M, Murphy K

Altered cerebrovascular response to acute exercise in patients with Huntington's disease
Brain Commun
Abr 16, 2020
2 (1) :fcaa044
PMID: 32566927
PMCID: 7293798

Fazio P, Fitzer-Attas CJ, Mrzljak L, Bronzova J, Nag S, Warner JH, Landwehrmeyer B, Al-Tawil N, Halldin C, Forsberg A, Ware J, Dilda V, Wood A, Sampaio C, Varrone A, PEARL-HD and LONGPDE10 study collaborators

PET molecular imaging of phosphodiesterase 10A: An early biomarker of Huntington's disease progressio
Mov Disord
Abr 03, 2020
35 (4) :606-615
PMID: 31967355

Goh AMY, You E, Perin S, Lautenschlager NT, Clay FJ, Loi SM, Chong T, Ames D, Chiu E, Ellis KA

Alcohol use, mental health, and functional capacity as predictors of workplace disability in a cohort with manifest Huntington's disease
J Neuropsychiatry Clin Neurosci
Feb 27, 2020
PMID: 32102602

Julayanont P, McFarland NR, Heilman KM

Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence
J Neurol Sci
Ene 15, 2020
408 :116523
PMID: 31678902

Ciosi M, Maxwell A, Cumming SA, Hensman Moss DJ, Alshammari AM, Flower MD, Durr A, Leavitt BR, Roos RAC, TRACK-HD team, Enroll-HD team, Holmans P, Jones L, Langbehn DR, Kwak S, Tabrizi SJ, Monckton DG

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes
EBioMedicine
Oct 10, 2019
48 :568-580
PMID: 31607598
PMCID: 6838430

Drew CJG, Quinn L, Hamana K, Williams-Thomas R, Marsh L, Dimitropoulou P, Playle R, Griffin BA, Kelson M, Schubert R, Muratori L, Reilmann R, Rosser A, Busse M

Physical activity and exercise outcomes in Huntington disease (PACE-HD): Protocol for a 12-month trial within cohort evaluation of a physical activity intervention in people with Huntington disease
Phys Ther
Sep 01, 2019
99 (9) :1201-1210
PMID: 31101920
es_ESES

Plataforma de investigación clínica

Enroll-HD es una plataforma de investigación clínica y el estudio observacional más grande del mundo para familias con enfermedad de Huntington.

Para centros de estudio

¡Muy pronto! Recursos operativos para sitios de estudio, incluido el acceso al portal de capacitación.