Revisiting vitamin therapy for HD
A research group in Spain is planning a clinical trial to explore if biotin and thiamine supplementation may help treat motor symptoms of Huntington’s Disease. This strategy emerged from their observations that some protein changes in both mice and people with the HD gene mutation resembled those seen in another rare brain disorder, biotin-thiamine responsive […]
A spoonful of branaplam helps the huntingtin go down
Scientists at Novartis and The Children’s Hospital of Philadelphia have recently published a paper detailing how the drug branaplam, originally developed for the neurological disease spinal muscular atrophy (SMA), could be repurposed to treat Huntington’s disease. Branaplam can lower levels of the huntingtin protein and is now being tested in the clinic in a phase […]
Huntington’s disease therapeutics conference 2022 – Day 3
Good morning! Today is the 3rd and final day of the #CHDI HD Therapeutics Conference in Palm Springs. Follow our feed today to get live updates! Biomarkers and clinical tools The fourth session of research talks will cover biomarkers and clinical tools for diagnosing, tracking, and treating HD. It is being introduced by Dr. Edith […]
Huntington’s disease therapeutics conference 2022 – Day 2
Good morning and welcome to Day 2 of HDBuzz coverage of the CHDI HD Therapeutics conference! Innovative approaches for HD therapeutics Chairing the third session of HD research talks is Dr. Michael Finley (CHDI) and Dr. William Martin (Janssen R&D, LLC) are chairing the third session of HD research talks, which will cover innovative approaches […]
Huntington’s disease therapeutics conference 2022 – Day 1
Good morning from sunny Palm Springs! After a 2-year hiatus because of COVID, the HD Therapeutics Conference is back in person this year – the biggest annual gathering of HD researchers! Our Twitter updates are compiled below. Continue to follow live updates for the rest of the conference with the hashtag #HDTC2022. Day 1 is […]
Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time
A recent addition to the Huntington’s disease research toolkit lets us “see” how well huntingtin lowering drugs are working in the brains of HD animal models. An international collaboration of scientists from Belgium, Germany, the U.S.A. and the U.K. tested their recently developed tool, called a PET ligand, in HD mouse models. When these mice […]