August 2025: This Month In Huntington’s Disease Research
This month’s Huntington’s disease (HD) research roundup spans work from the dinner table to DNA repair. Scientists explored whether eating on a schedule could help clear toxic proteins, uncovered early signs of muscle loss in HD, and examined how childhood experiences shape adult mental health. Other teams investigated the gut–brain connection, identified new protein biomarkers, […]
When DNA Repair Goes Off Script: How a Small Change in FAN1 Can Accelerate Huntington’s Disease
Two research teams have uncovered how a small change in FAN1, a DNA repair protein, can speed up Huntington’s disease (HD). In back-to-back papers in Nature Communications, they show how a single mutation known to influence when symptoms begin appears to prevent FAN1 from working properly. This seems to make it harder for cells to […]
Cracking the Protein Puzzle in HD: New Blueprints Offer Hope for Stopping Damage Early
Two studies from the same research group have helped to provide some important blueprints for Huntington’s disease (HD) research, helping us to more clearly understand what the toxic fragment form of the expanded huntingtin protein is doing. The first study maps the structure of the toxic fragment protein, called exon 1, that clumps together to […]
City Under the Microscope: How Two Proteins Could Help Track Huntington’s Disease
Biomarkers are measurable signs of what’s happening inside the body and are essential for running successful Huntington’s disease (HD) trials. Right now, neurofilament light (NfL) is the star of the HD biomarker world, but we need more players on the team. A new study from Cyprus scanned every type and amount of protein molecules found […]
The Gut–Brain Superhighway in Huntington’s Disease: Clues From the Microbes Inside Us
While Huntington’s disease (HD) primarily affects the brain, the genetic change that causes the disease is present in every cell throughout the body. Because of that, it has influences beyond the brain, including in the gut. Increasing evidence suggests that changes in gut microbes, leaky barriers, inflammation, and nerve signaling may contribute to HD progression. […]
Carried from Childhood: Childhood Experiences and Adult Mental Health in Families with Huntington’s Disease
For many people raised in families affected by Huntington’s disease (HD), childhood isn’t just about scraped knees and schoolbooks. It can also mean living with uncertainty, emotional turbulence, and a silence that’s hard to navigate. While much of the focus is on the person with HD, a growing body of research is beginning to ask […]
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