How Big Is The Huntington’s Disease Iceberg?
Huntington’s disease (HD) is caused by repeating C-A-G letters of genetic code that are too long. Everyone who develops HD is born with 36 or more CAG repeats, but not everyone with 36 or more CAG repeats is actually diagnosed with HD. That’s because either they are not old enough yet to have symptoms, or […]
Huntington’s Disease Clinical Research Congress 2025 – Day 3
Welcome back for the final day of the Huntington’s Disease (HD) Clinical Research Congress in Nashville, Tennessee! Translational issues in HD The first session will focussed on translational issues in HD – how we get research to people that need it most, HD families. Dr. Sarah Tabrizi from UCL opened with an introduction discussing translational issues […]
Huntington’s Disease Clinical Research Congress 2025 – Day 2
We’re back for Day 2 of Huntington’s Disease (HD) Clinical Research Congress in Nashville, Tennessee! Daniel Claassen from HSG and Cristina Sampaio from CHDI kick off the meeting with an overview of what we’ll hear about in HD clinical research and discovery. They are highlighting the search for biomarkers, the buzz over recent results from […]
Huntington’s Disease Clinical Research Congress 2025 – Day 1
This month, HDBuzz is attending the first Huntington’s Disease (HD) Clinical Research Congress in Nashville, Tennessee. Gathered at this meeting are hundreds of scientists, doctors, and industry representatives who have come together to talk about HD clinical research and care. This conference has been organized by the Huntington Study Group (HSG) and CHDI Foundation, big […]
Controlling DNA Scanning Machines to Slow Expansion of CAG Repeats
A team of scientists have discovered small molecules that block the DNA repair protein MSH3, thought to be a key driver of repeat expansion in Huntington’s disease (HD). Although still at an early stage, this work opens the door to a new kind of therapeutic strategy: slowing down HD before symptoms begin. Let’s get into […]
2025 HDBuzz Prize: When Good Huntingtin Goes Missing: A Step Toward Designing Safe HD Treatments
A new study has shed light on the role of the regular huntingtin protein in the brain. For years, researchers have known that the faulty expanded huntingtin protein drives Huntington’s disease (HD), but this new study shows why the regular version matters for brain health. By lowering regular huntingtin (HTT) in brain cells, scientists discovered […]
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