Blocking a toxic fragment: new mouse study highlights the importance of HTT1a in Huntington’s disease
⏱️ 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next generation of HTT-lowering therapies. Read more
Between Care, Genes, and Systems: Navigating Huntington’s Disease as a Caregiver
A small study based in Ireland asked a simple question: what does caring for someone with Huntington’s disease feel like? The answers point to isolation, stigma, and major gaps in healthcare support for many of the respondents. Read more
Your Wrist on Watch: Could a Smartwatch Reveal Huntington’s Disease Symptoms?
⏱️ 7 min read | A wrist sensor tracked arm movements in people with HD for a week and could see who had HD and who didn’t. This kind of technology could change how we measure drug effects in trials. Read more
March 2026: This Month in Huntington’s Disease Research
⏱️ 9 min read | March brought us the annual CHDI therapeutics conference along with updates from 3 ongoing clinical trials. We also covered new research on somatic expansion and honored the community that built our science during Gratitude Day. Read more
Two Heads Are Better Than One: Combined Physical and Music Therapy for Late-Stage Huntington’s Disease
A new study looking into combined music and physical therapy shows that simple rhythmic cues work better than complex music or instructions, helping to improve movement control and reducing chorea. Read more
A Guest Perspective for Gratitude Day: Why Huntington’s Disease May Be Neuroscience’s Best Investment
⏱️ 6 min read | Today, on Gratitude Day, we share a guest piece from HD researcher Roy Maimon that Huntington’s disease is neuroscience’s best investment, not just for its scientific clarity, but for the remarkable community built around it. Read more
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