Nourrir le cerveau par l'intestin : comment les prébiotiques pourraient influencer la maladie de Huntington
When it comes to thinking about the effects of Huntington’s disease (HD), most people automatically start to think about the brain due to the severe symptoms caused by the breakdown of brain cells. It’s easy to forget that the gene which causes HD is present throughout the whole body – including in the gut! Recent […]
Un vieux médicament, de nouvelles astuces : la sertraline pourrait alléger la charge dans la maladie de Huntington en ciblant la production de protéines
Depression and anxiety are common symptoms of Huntington’s disease (HD), and they can make everything harder. New research explores how sertraline, a widely-used antidepressant, affects protein production in HD cells and mice, finding that it prevents motor problems in HD mice and is linked to slower functional decline in people with HD. This study raises […]
Novembre 2025 : Ce mois-ci dans la recherche sur la maladie de Huntington
Welcome back to the HDBuzz monthly research roundup! November was a busy month, with new developments in everything from gene therapy and stem cells to DNA repair, genetic modifiers, and protein folding. Here’s a friendly guide to what scientists learned this month, why it matters, and what it might mean for the future of Huntington’s […]
Plier une chemise avec des bras de 3,65 mètres : comprendre le repliement des protéines dans la maladie de Huntington
Imagine a busy clothing factory. Proteins are like newly sewn shirts coming off the machines. They’re floppy, wrinkled, and can create a giant mess if they’re left unfolded. Normally, the cellular clothing factory employs “chaperone proteins” that act like skilled pressers. They grab each shirt, apply energy from a hot iron, and carefully fold it […]
Le SOM3355 passe en phase 3, l'EMA et la FDA ayant émis un signal favorable.
SOM3355 is an investigational therapy aimed at managing multiple symptoms of Huntington’s disease (HD) and recently crossed two key regulatory milestones. In September, the European Medicines Agency (EMA) issued a positive opinion supporting orphan drug designation for SOM3355. Now, following a productive End-of-Phase-2 meeting in the United States, the US Food and Drug Administration (FDA) […]
Une minuscule modification génétique pourrait retarder les symptômes et activer le nettoyage cellulaire dans la maladie de Huntington
Scientists often use genetics, the study of DNA, to understand the cellular changes that cause disease. By comparing people’s DNA with their symptoms, they can pinpoint specific genetic differences, called variants, that influence the severity of a disease. Huntington’s disease (HD) is well-suited for genetic analysis because of its well-understood genetic roots – an expansion […]
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