Aufregung und Vorfreude: PTCs Medikament gegen die Huntington-Krankheit nimmt eine große Hürde und ist schnell auf dem Weg nach Hause
On May 5th, PTC Therapeutics released results from their ongoing Phase 2 PIVOT-HD clinical trial for PTC-518, now called votoplam. Excitingly, they announced that this trial met its primary endpoint – votoplam was shown to lower huntingtin protein levels. We also learned more about the safety of this drug and some insights into how it […]
Was gut für Ihr Herz ist, ist gut für Ihr Gehirn: Neue Studie verbindet Herz-Kreislauf-Gesundheit mit der Alterung des Gehirns
We all know heart health matters – but what if the same habits that keep your heart strong could also protect your brain? A new study reveals a link between cardiovascular health and lower levels of neurofilament light (NfL), a key biomarker of brain cell damage for Huntington’s disease (HD) research. So what does this […]
Fließbandausfall: Probleme bei der Proteinproduktion bei der Huntington-Krankheit
Imagine a vast and intricate factory, humming with activity. This factory isn’t manufacturing cars or electronics but rather the essential components that keep our bodies running. Inside each cell, thousands of tiny workers, known as proteins, perform highly specialized tasks. These proteins are responsible for everything from building cellular structures to sending messages and cleaning […]
April 2025: Dieser Monat in der Huntington-Forschung
April was blooming with fresh updates from the world of Huntington’s disease (HD) research, and we’ve got your highlights right here! At HDBuzz, we’re always on the lookout for promising science, innovative ideas, and stories that bring hope. This month, we covered exciting breakthroughs in basic research, important clinical trial updates, and fresh perspectives on […]
Stopp der CAG-Wiederholungsausbreitung
A new study led by researchers at University College London explored a promising new way to potentially slow down Huntington disease (HD) by reducing the levels of a key DNA repair protein, called MSH3. Using antisense oligonucleotides (ASOs)—a type of genetic therapy that targets RNA—the researchers successfully stopped C-A-G repeat expansions in lab-grown brain cells […]
Beeinflussen Antidepressiva den kognitiven Abbau? Die Geschichte der Huntington-Krankheit hat noch mehr zu bieten.
Zwei aktuelle Studien liefern neue Erkenntnisse darüber, wie Antidepressiva, die häufig zur Linderung von Stimmungsschwankungen und Angstzuständen verschrieben werden, bei der Huntington-Krankheit (HK) eingesetzt werden und möglicherweise auch den kognitiven Abbau beeinflussen. Eine Studie untersucht den Medikamentengebrauch bei HK, die andere den Zusammenhang zwischen Demenz und Antidepressiva. Zusammen zeigen sie ein komplexes und […]
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